Zee et al. (JASN 33, 2022) identified kidney biopsy features most predictive of clinical outcomes in the spectrum of minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) using data from the Nephrotic Syndrome Study Network (NEPTUNE, https://www.neptune-study.org/). These included conventional and novel histologic and ultrastructural parameters from both glomerular and tubulointerstitial renal compartments. Biopsy reports for MCD and FSGS can be standardized by scoring and reporting of these descriptors of structural tissue changes.